DR-314 The whole genome mutational landscape of APOBEC-driven urothelial carcinomas
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- Zeldzame kankers
DR-314 The whole genome mutational landscape of APOBEC-driven urothelial carcinomas
Urothelial carcinoma (UC) is characterized by high mutational burden with a large proportion of genomic alterations associated with APOBEC mutagenesis. …
DR-331 The landscape of germline-somatic interactions
Summary = Inherited genetic factors are known to contribute to the risk of developing different types of tumors and to influence …
DR-302 Virus-Induced Cell-Cell Fusion as a Driver of Metastasis
Many viruses that commonly infect humans have been found to fuse cells. Evidence suggests that the products of cell fusion …
DR-359 Genomic Landscape of Metastatic Cancer with known primary compared to Cancer of Unknown primary
Based on our DR-196 data request for Cancer of Unknown Primary (CUP) we predicted the primary tumor of multiple patients …
DR-364 Microbiome in metastatic cancer
In this study we will investigate the microbiome in metastatic cancer. We will use whole genome sequencing data from solid …
DR-363 Identification of functional intergenic genomic fusions
Predicting the functional outcomes of genomic rearrangements is challenging due to the intricate nature of rearrangement patterns. Consequently, studies on …
DR-351 Processes regulating cancer metastasis and disease progression
We aim to identify and characterize the molecular and cellular factors that distinguish cancer cells that metastasize from cancer cells …
DR-347 Comprehensive characterization of the immunogenomic landscape of metastatic tumors
Escape from immune surveillance is one of the hallmarks of tumorigenesis. In this study, we aim to perform an extensive …
DR-360 Xenobiotic metabolizers in bladder cancer progression
Metastasis marks the culmination of tumorigenesis and is the leading cause of mortality in cancer. The underlying molecular processes that …
DR-355 Mapping the germline genetic architecture of cancer using genome sequencing
Cancer is a leading cause of death worldwide, but many tumors are treatable if intercepted at an early stage. Thus, …
DR-335 Leveraging mutational processes to uncover cancer biomarkers
Cancers develop due to a range of genomic alterations, of which mutations are the most frequent. Sequencing cancer genomes reveals …
DR-346 Investigating Immune Evasion in Gastrointestinal Malignancies
Colon, rectal, stomach, and esophageal cancers are able to evade detection from our immune system, however the way these tumors …
Kankers zullen steeds vaker voldoen aan de definitie van ‘zeldzaam’ als het gaat om de moleculaire profielen die elke tumor uniek maakt. Hoe meer onderzoek we hiernaar doen, hoe beter we in de toekomst elke patiënt een op maat gemaakte behandeling kunnen aanbieden. Whole genome sequencing en studies als DRUP leveren hier een belangrijke bijdrage aan.