DR-370 Molecular mechanisms underlying the metastatic progression
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DR-370 Molecular mechanisms underlying the metastatic progression
Metastasis is responsible for the failure of cancer treatment and patient mortality. Thanks to the unprecedented opportunity to study the …
DR-362 Genetic factors of disease progression and therapy response in cutaneous squamous cell carcinoma
Squamous cell cancer (SCC) of the skin is the second most common type of cancer world-wide. While many patients can …
DR-337 Connecting telomere dysfunction, tumorigenesis and cancer evolution using short-read DNA and RNA sequencing data
The Barthel lab uses advanced sequencing and molecular approaches to study the development and evolution of brain tumors. We have …
DR-240 Genomic signatures of HR deficiency in advanced ovarian cancer
Cancers with defects in DNA repair pathways can be sensitive to certain therapies. One way to identify cases with these …
DR-341 Characterization of immunogenicity of mutations
Some tumor show spectacular effect of immunotherapy, while other tumors show only limited response. Finding biomarkers to predict this response, …
DR-314 The whole genome mutational landscape of APOBEC-driven urothelial carcinomas
Urothelial carcinoma (UC) is characterized by high mutational burden with a large proportion of genomic alterations associated with APOBEC mutagenesis. …
DR-331 The landscape of germline-somatic interactions
Summary = Inherited genetic factors are known to contribute to the risk of developing different types of tumors and to influence …
DR-302 Virus-Induced Cell-Cell Fusion as a Driver of Metastasis
Many viruses that commonly infect humans have been found to fuse cells. Evidence suggests that the products of cell fusion …
DR-359 Genomic Landscape of Metastatic Cancer with known primary compared to Cancer of Unknown primary
Based on our DR-196 data request for Cancer of Unknown Primary (CUP) we predicted the primary tumor of multiple patients …
DR-364 Microbiome in metastatic cancer
In this study we will investigate the microbiome in metastatic cancer. We will use whole genome sequencing data from solid …
DR-363 Identification of functional intergenic genomic fusions
Predicting the functional outcomes of genomic rearrangements is challenging due to the intricate nature of rearrangement patterns. Consequently, studies on …
DR-351 Processes regulating cancer metastasis and disease progression
We aim to identify and characterize the molecular and cellular factors that distinguish cancer cells that metastasize from cancer cells …
Deze complete DNA-test maakt de individuele behandeling mogelijk en beperkt daarmee onwenselijke bijwerkingen.