DR-395 Predicting the landscape and dynamic of cancer drivers from cancer initiation to metastasis
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DR-395 Predicting the landscape and dynamic of cancer drivers from cancer initiation to metastasis
Cancer initiation and progression are a result of acquiring alterations in genes that confer a selective advantage to the cell …
DR-382 An international multicenter retrospective study on the efficacy of anti-PD-(L)1 monotherapy in microsatellite unstable castrate-resistant prostate cancer
Metastatic castrate-resistant prostate cancer (mCRPC) is generally insensitive to immune checkpoint inhibitor therapy (ICIs), partly due to its relatively low …
DR-383 Drug resistance in cancer from in vitro genetic screens
Drug resistance is a major limitation to the long-term efficacy of cancer drugs. The use of cancer genome sequencing has …
DR-392 Targeting Genetic Alterations Associated with Metastatic Clear Cell Renal Cell Carcinoma
We aim to perform an integrated analysis of the genetic alterations associated with metastatic clear cell renal cell carcinoma (ccRCC) …
DR-389 Multi-omics pan-cancer profiling
The changes to the DNA (mutations) found in a tumour are expected to be largely unique to each tumour as …
DR-393 Distinctive size classes of loss of heterozygosity and homozygous deletion and its association with cancer progression and DNA repair pathways
Previous work from our institute has been published on analysis of WGS data that were made accessible by the Hartwig …
DR-377 Characterising the mutational landscape and recurrent somatic driver events to uncover therapeutic susceptibilities in pancreatic cancer
Pancreatic Adenocarcinoma (PAAD) has the highest rate of morbidly for all solid tumours, and with pancreatectomy possible in <20% patients, …
DR-384 The influence of the germline deletion polymorphism of chromosome 8 (ADAM3A/ADAM5 locus) on the expression of genes and pathways involved in carcinogenesis
Our data from 218 patients with esophageal adenocarcinoma (EAC) , treated with neo-adjuvant chemoradiotherapy (CROSS schema), show a worse prognosis …
DR-388 The prevalence and burden of rare deleterious germline variants in cancer predisposition genes
The goal of this project is to identify germline variants that result in higher chances to develop cancer, since these …
DR-353 Landscape of mutational signatures in appendiceal cancer
Appendiceal cancer is still a poorly understood entity. There are many subtypes and treatment decisions are often made based on …
DR-367 Examining the effects of microbial colonization of cancer and its role in metastasis
In many cancers, microbiota have emerged as an influential component of the tumor environment. However, the extent to which microbiota …
DR-390 Exploring the impact of tumor microenvironment, biological ageing and immune health on cancer initiation, development, and treatment response
Cancer is a complex disease, characterized by a wide spectrum of genome abnormalities. However, emerging data indicates that genomic drivers may …
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