DR-361 A systematic analysis for the cancer fitness landscape between primary and metastatic tumors
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DR-361 A systematic analysis for the cancer fitness landscape between primary and metastatic tumors
We aim to demonstrate that the optimal activity-fitness level (cancer fitness) of cancer genes can vary depending on the tumor …
DR-425 Investigation of mutational processes and selection in cancer metastases
Cancer is a genetic disease driven by mutations in certain parts of the genome. We aim to study the distribution …
DR-429 Structural Variation Signatures and ABC transporters in Ovarian Cancer
This project explores the genomic heterogeneity of high-grade serous ovarian carcinoma (HGSC) by developing a method to identify structural variation …
DR-421 Molecular functions of steroid hormones in promoting prostate cancer progression
Prostate cancer relies on steroid hormones for development and progression. Hence, targeting steroid hormone pathways by androgen deprivation therapy (ADT) …
DR-412 Breast cancer with APOBEC mutagenesis evolve during progression
APOBEC mutagenesis are more profoundly present in metastatic breast cancer, particularly in ER+/HER2- breast cancer. This suggests that APOBEC driven …
DR-413 Identifying non-coding driver regions in cancer using Machine Learning
Patients with some types of cancer can have their tumor DNA sequenced to identify tumor variants. The identification of specific …
DR-366 The biomarker landscape of metastatic cance
In this project, we will perform a detailed assessment of tumor DNA and RNA characteristics that predict if patients with …
DR-408 Integrative discovery of genomic and transcriptomic drivers of pan-cancer metastatic phenotypes
Cancer is driven by mutations in DNA that activate cancer-causing genes and disable protective genes, causing cells to grow infinitely. …
DR-414 Neoantigen discovery and validation for therapeutic vaccine development
Developing effective cancer therapies is challenging, often benefiting only specific patient groups. The Oncode Accelerator consortium aims to innovate this …
DR-376 Clinical and Functional Interpretation of Whole Genome Sequencing
This project will examine how whole genome sequencing (WGS) may improve the diagnosis and treatment of cancer. First, we will …
DR-416 Mutational signatures of Topoisomerase I poisons in cancer cell models and human tumours
DNA Topoisomerase 1 (Top1) relieves DNA supercoils. Top1 poisons, such as irinotecan, inhibit Top1 DNA religation activity causing DNA breaks, …
DR-401 IMPACT-HPB: Integrative Machine learning for Predictive Assessment and Customized Treatment in Hepato-Pancreato-Biliary Cancers
Hepato-pancreato-biliary (HPB) cancers pose a significant oncological challenge with high mortality rates. Despite diagnostic and therapeutic advancements, prognosis remains poor, …
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