DR-408 Integrative discovery of genomic and transcriptomic drivers of pan-cancer metastatic phenotypes
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DR-408 Integrative discovery of genomic and transcriptomic drivers of pan-cancer metastatic phenotypes
Cancer is driven by mutations in DNA that activate cancer-causing genes and disable protective genes, causing cells to grow infinitely. …
DR-414 Neoantigen discovery and validation for therapeutic vaccine development
Developing effective cancer therapies is challenging, often benefiting only specific patient groups. The Oncode Accelerator consortium aims to innovate this …
DR-376 Clinical and Functional Interpretation of Whole Genome Sequencing
This project will examine how whole genome sequencing (WGS) may improve the diagnosis and treatment of cancer. First, we will …
DR-416 Mutational signatures of Topoisomerase I poisons in cancer cell models and human tumours
DNA Topoisomerase 1 (Top1) relieves DNA supercoils. Top1 poisons, such as irinotecan, inhibit Top1 DNA religation activity causing DNA breaks, …
DR-401 IMPACT-HPB: Integrative Machine learning for Predictive Assessment and Customized Treatment in Hepato-Pancreato-Biliary Cancers
Hepato-pancreato-biliary (HPB) cancers pose a significant oncological challenge with high mortality rates. Despite diagnostic and therapeutic advancements, prognosis remains poor, …
DR-358 Spatial and longitudinal heterogeneity of liver tumors across ages shaped by interaction between genetics and environment
We aim to decipher the clonal and phenotypic evolution of liver tumors based on genomic analysis of large cohorts (our …
DR-419 Characterizing the role of cytidine deaminase in cancer progression and metastasis
The incidence of cancer is a major health problem worldwide, however the mechanistic basis of cancer development and intervention to …
DR-394 Uncovering immunoediting strategies and hallmark ordering underlying metastatic transformation across tumours
This project seeks to unravel the complex process by which cancer outsmarts the immune system, a critical challenge in cancer …
DR-369 A method to infer substitution mutational signatures while correcting for local mutation rates biases
Vulnerability of the DNA to damage is influenced by (epi)genomic features and tissue specific properties of the DNA repair machinery. …
DR-357 Expanded Structural Variant Signatures and their Role in Predicting Chemotherapy Sensitivity
The type of genetic alteration that affects the largest fraction of the genome in cancer is alterations in chromosome structure, …
DR-397 Genomic and transcriptional determinants of chromosomal instability (CIN) in the tumor evolution and progression of GIST and genomically simple sarcomas
Unlike normal cells, cancer cells frequently display chromosomal instability (CIN), causing genetic material loss or rearrangement during cell division. Our …
DR-396 The impact of individual mutational processes on evolution of cancer
Drug resistance is a major cause of cancer recurrence and related deaths, often due to DNA mutations in cancer cells …
Uit mijn eigen ervaring weet ik hoe belangrijk de kennis kan zijn over erfelijke aanleg voor kanker. Daarom vind ik het ook zo belangrijk dat een compleet patiëntrapport juist ook die dragerschap informatie bevat, als de patiënt daarvoor kiest die te willen weten.