DR-358 Spatial and longitudinal heterogeneity of liver tumors across ages shaped by interaction between genetics and environment
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DR-358 Spatial and longitudinal heterogeneity of liver tumors across ages shaped by interaction between genetics and environment
We aim to decipher the clonal and phenotypic evolution of liver tumors based on genomic analysis of large cohorts (our …
DR-419 Characterizing the role of cytidine deaminase in cancer progression and metastasis
The incidence of cancer is a major health problem worldwide, however the mechanistic basis of cancer development and intervention to …
DR-394 Uncovering immunoediting strategies and hallmark ordering underlying metastatic transformation across tumours
This project seeks to unravel the complex process by which cancer outsmarts the immune system, a critical challenge in cancer …
DR-369 A method to infer substitution mutational signatures while correcting for local mutation rates biases
Vulnerability of the DNA to damage is influenced by (epi)genomic features and tissue specific properties of the DNA repair machinery. …
DR-357 Expanded Structural Variant Signatures and their Role in Predicting Chemotherapy Sensitivity
The type of genetic alteration that affects the largest fraction of the genome in cancer is alterations in chromosome structure, …
DR-397 Genomic and transcriptional determinants of chromosomal instability (CIN) in the tumor evolution and progression of GIST and genomically simple sarcomas
Unlike normal cells, cancer cells frequently display chromosomal instability (CIN), causing genetic material loss or rearrangement during cell division. Our …
DR-396 The impact of individual mutational processes on evolution of cancer
Drug resistance is a major cause of cancer recurrence and related deaths, often due to DNA mutations in cancer cells …
DR-399 Molecular signature scores related to intratumor heterogeneity and stemness to improve prognostic accuracy and facilitate the development of more personalized treatment strategies for breast cancer
We aim to characterize Immuno-evasive stem cells genetic signatures to better understand their behavior within breast cancer. These cells play …
DR-407 Liver metastases exhibit a distinct myeloid-dominated tumor microenvironment characterized by dense infiltration of VEGFR1+ VEGF-A-secreting macrophages
Liver metastases (LM) are a major obstacle for patients with advanced non-squamous non-small cell lung cancer. We stratified 1,713 treatment-naïve …
DR-402 Predicting response to immune-checkpoint inhibitors in metastatic cancer using Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score
Immune checkpoint inhibitors (ICIs) have significantly improved clinical outcomes of patients with metastatic cancers. In clinical practice, three biomarkers are …
DR-385 Development of computational multi-omics strategies for targeting therapeutically the tumour metastasis and tumour microenvironment heterogeneity
Identifying the most appropiate therapies based on cancer genome data is a major challenge in personalized cancer medicine. Physicians and researchers face …
DR-375 AI-driven classification of metastatic tumors with MSI/MSS phenotypes: an integrative computational and clinical perspective
We aim to provide insights into cancer progression and therapy responsiveness by combining diverse molecular sequence data using an AI-driven multimodal classifier. …
Het aantal WGS- samples dat Hartwig Medical Foundation heeft, is uniek in het onderzoeksveld en groeit snel. Toen we begonnen waren het er 3.500 en dat zijn er nu al meer dan 5.000.