DR-430 New transcriptional subgroups of colorectal cancer patients harbouring the BRAF V600E mutation
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DR-430 New transcriptional subgroups of colorectal cancer patients harbouring the BRAF V600E mutation
Colorectal cancer (CRC) remains the second most common cause of cancer death in the world. Approximately 12 % of CRC patients have a mutation in the …
DR-427 The role of whole genome doubling in cancer evolution and diagnostics
Whole genome doubling (WGD) is one of the most frequent aberrations that disrupt the genome of cancers. WGD is associated …
DR-424 Dissecting cancer cell-intrinsic mechanisms dictating the immune landscape of cancer
Immunotherapy has shown great success in treating multiple cancer types. However, not all patients benefit from immunotherapy. We are studying why …
DR-422 Investigating the mechanisms of epithelial/mesenchymal plasticity and metastasis
Metastasis to distant organs is the major cause of cancer-related deaths. The recent advancements in DNA sequencing technology, have significantly …
DR-432 Exploring molecular mechanisms involved in lung cancer progression and prediction of clinical outcomes
This project aims to improve lung cancer treatment by studying the complete genetic makeup of cancer cells. We will use …
DR-404 PRIME-ROSE
The PRIME-ROSE project (Precision Cancer Medicine Repurposing System Using Pragmatic Clinical Trials) is a European initiative to make targeted therapies—originally …
DR-361 A systematic analysis for the cancer fitness landscape between primary and metastatic tumors
We aim to demonstrate that the optimal activity-fitness level (cancer fitness) of cancer genes can vary depending on the tumor …
DR-425 Investigation of mutational processes and selection in cancer metastases
Cancer is a genetic disease driven by mutations in certain parts of the genome. We aim to study the distribution …
DR-429 Structural Variation Signatures and ABC transporters in Ovarian Cancer
This project explores the genomic heterogeneity of high-grade serous ovarian carcinoma (HGSC) by developing a method to identify structural variation …
DR-421 Molecular functions of steroid hormones in promoting prostate cancer progression
Prostate cancer relies on steroid hormones for development and progression. Hence, targeting steroid hormone pathways by androgen deprivation therapy (ADT) …
DR-412 Breast cancer with APOBEC mutagenesis evolve during progression
APOBEC mutagenesis are more profoundly present in metastatic breast cancer, particularly in ER+/HER2- breast cancer. This suggests that APOBEC driven …
DR-413 Identifying non-coding driver regions in cancer using Machine Learning
Patients with some types of cancer can have their tumor DNA sequenced to identify tumor variants. The identification of specific …
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